Brighton host rivals Crystal Palace at the AMEX Stadium as they meet in the Premier League.
Nigel Pearson's Watford welcome title-chasing Liverpool to Vicarage Road in the Premier League. A Mohamed Salah brace was enough to see the Reds over the lines in the reverse game.
Carlo Ancelotti's Everton take on Manchester United at Goodison Park in the Premier League. The sides shared the spoils in a 1-1 draw in the reverse fixture.
Hoping to earn a spot in the quarter-finals, Arsenal travel to Fratton Park to take on League One side Portsmouth in the fifth round of the FA Cup.